Molecular Markers and Changes of Computed Tomography Appearance in Lung Adenocarcinoma with Ground-glass Opacity

Yukihiro Yoshida,et al. Molecular Markers and Changes of Computed Tomography
Appearance in Lung Adenocarcinoma with Ground-glass Opacity. Jpn J Clin Oncol 2007;37(12)907–912

6ヵ月以上経過観察された23例の肺腺癌をCT所見の経時的変化により分類し、表皮成長因子受容体（EGFR）の変異分析・K-ras遺伝子・p53タンパク質の免疫組織化学的染色と比較した。GGOを有する肺腺癌ではEGFR変異が頻繁に認められた。p53の不活性化は高濃度域の出現と関連している可能性がある。

Methods:Patterns of radiological changes during the follow-up period were classified into three groups; type 1, pure GGO without consolidation; type 2, appearance or increase in consolidation within pure GGO; type 3, consolidation without pure GGO. Mutational analysis of the epidermal growth factor receptor (EGFR) and K-ras genes and immunohistochemical staining of p53 protein were performed.
Results: EGFR mutations were found in 17 cases (74%), and there was no K-ras mutation. Positive staining of p53 was found in 8 cases (35%). As for radiological findings during the follow-up period, the frequencies of EGFR mutations and positive p53 staining were 67 and 0% in type 1 (n＝9), 89 and 44% in type 2 (n＝ 9) and 60 and 80% in type 3 (n＝5).